製品の概要

  • 製品名(-)-Bicuculline methochloride
  • 製品の詳細
    GABAA antagonist
  • 生理活性の詳細Water-soluble GABAA antagonist. Methochloride salt of (+)-bicuculline (ab120107). Actions on neuronal Ca2+-activated K+ channels reported.

    Also available in simple stock solutions (ab146682) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 精製度> 99%

製品の特性

    (-)-Bicuculline methochloride 画像

    • Current clamp recordings demonstrating that the depolarisation of ependymal cells in response to GABA (200 μM) is partially antagonised by bicuculline (ab120110, 100 μM) in a reversible manner.
    • Group data for responses to GABA alone or in the presence of bicuculline (bic, ab120110) and/or nipecotic acid (NA).

    (-)-Bicuculline methochloride (ab120110) 使用論文

    This product has been referenced in:
    • Seutin V & Johnson SW Recent advances in the pharmacology of quaternary salts of bicuculline. Trends Pharmacol Sci 20:268-70 (1999). Read more (PubMed: 10390643) »
    • Olsen RW  et al. Studies on the neuropharmacological activity of bicuculline and related compounds. Brain Res 102:283-99 (1976). Read more (PubMed: 1247886) »

    See all 5 Publications for this product

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    Thank you for contacting Abcam.

    Unfortunately we don’t have a pKa value listed for this compound. I have done a quick literature search and nothing seems to be coming up.

    Usually if we have any such figures (IC50, Kd, pKa) we wo...

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