(-)-Bicuculline methobromide, GABAA antagonist (ab120109)
Key features and details
- GABAA antagonist
- CAS Number: 73604-30-5
- Soluble in water to 100 mM
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(-)-Bicuculline methobromide, GABAA antagonist -
製品の詳細
GABAA antagonist -
CAS 番号
73604-30-5 -
構造式
製品の特性
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体系名
[S-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide -
分子量
462.29 -
分子式
C21H20BrNO6 -
PubChem 登録番号
171729 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in water to 100 mM -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[Br-] -
由来
Synthetic
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研究分野
関連製品
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Related Products
画像
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2D chemical structure image of ab120109, (-)-Bicuculline methobromide, GABAA antagonist
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Saturation of LTP by nicotine application.
VSD recordings were performed from the granular layer of cerebellar slices (pre-treated with 10 µM bicuculline methobromide) to measure the spatial organisation of the effect of nicotine following TBS.
(Panel A) Images of background epifluorescence in stained cerebellar slices show the granular layer (GRL), Purkinje cell layer (PCL), molecular layer (ML), mossy fibre bundle (mf), and position of the stimulating electrode (yellow dots). Coloured optical maps of granular layer activity evoked by a single mossy fibre pulse are compared before and after the induction of long-term synaptic plasticity by TBS.
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (11)
ab120109 は 11 報の論文で使用されています。
- Oku S et al. Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity. Elife 9:N/A (2020). PubMed: 32915137
- Chittajallu R et al. Activity-dependent tuning of intrinsic excitability in mouse and human neurogliaform cells. Elife 9:N/A (2020). PubMed: 32496194
- Ge Y et al. Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength. Neuron 97:596-610.e8 (2018). PubMed: 29395912
- Zhang P et al. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell 174:1450-1464.e23 (2018). PubMed: 30100184
- Kosillo P et al. Cortical Control of Striatal Dopamine Transmission via Striatal Cholinergic Interneurons. Cereb Cortex N/A:N/A (2016). PubMed: 27566978