(+)-Bicuculline, GABAA antagonist (ab120107)
Key features and details
- GABAA antagonist
- CAS Number: 485-49-4
- Soluble in ethanol to 5 mM and DMSO to 100 mM (with heating)
- Form / State: Solid
- Source: Synthetic
製品の概要
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製品名
(+)-Bicuculline, GABAA antagonist -
製品の詳細
GABAA antagonist -
生理活性の詳細
GABAA antagonist.
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CAS 番号
485-49-4 -
構造式
製品の特性
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体系名
[R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one -
分子量
367.35 -
分子式
C20H17NO6 -
PubChem 登録番号
10237 -
保存方法
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解性
Soluble in ethanol to 5 mM and DMSO to 100 mM (with heating) -
使用に関する注意
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES 線形表記
CN2CCc1cc6OCOc6cc1[C@H]2[C@@H]5OC(=O)c4c5ccc3OCOc34 -
由来
Synthetic
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研究分野
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
参考文献 (34)
ab120107 は 34 報の論文で使用されています。
- Mishra P & Narayanan R Conjunctive changes in multiple ion channels mediate activity-dependent intrinsic plasticity in hippocampal granule cells. iScience 25:103922 (2022). PubMed: 35252816
- Schröter M et al. Functional imaging of brain organoids using high-density microelectrode arrays. MRS Bull 47:530-544 (2022). PubMed: 36120104
- Blazon M et al. N-type calcium channels control GABAergic transmission in brain areas related to fear and anxiety. OBM Neurobiol 5:N/A (2021). PubMed: 33521586
- Dingle YL et al. Integrated functional neuronal network analysis of 3D silk-collagen scaffold-based mouse cortical culture. STAR Protoc 2:100292 (2021). PubMed: 33537680
- Malik AR et al. SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Cell Rep 26:2792-2804.e6 (2019). PubMed: 30840898